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Surgical Intervention Reserved for large goitres causing compressive symptoms or cosmetic concerns Subtotal thyroidectomy may be considered in select cases Prognosis ~5% of subclinical hypothyroid patients progress to overt disease per year

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404 R-SO2/3 modification of Cys38 and Cys214 enhances the interaction between MEK and ERK1/2, increasing the phosphorylation of ERK1/2 by MEK